EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.67 | JIB 04 | inhibitor is active against native and temozolomide-resistant glioblastoma cells. GSK J4, inhibitor of lysine demethylase KDM6B, EC 1.14.11.68, and JIB 04 strongly synergize and are a potent combination against temozolomide-resistant glioblastoma cells | Homo sapiens | |
1.14.11.68 | GSKJ4 | inhibitor is active against native and temozolomide-resistant glioblastoma cells, albeit at at a lower effcacy than JIB 04, inhibitor of lysine demethylase KDM5A, EC 1.14.11.67. GSK J4 and JIB 04 strongly synergize and are a potent combination against temozolomide-resistant glioblastoma cells. GSK J4 does not synergize with temozolomide | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.67 | Homo sapiens | P29375 | - |
- |
1.14.11.68 | Homo sapiens | O15054 | isoform KDM6B | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.67 | KDM5A | - |
Homo sapiens |
1.14.11.68 | KDM6B | - |
Homo sapiens |